
Prof. Dr. Vahid Sandoghdar
Chair of Experimental Physics
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Posts
Molecular hybridization through vacuum

Interactions between atoms and molecules are facilitated by electromagnetic fields. The bigger the distance between the partners involved, the weaker…
Publications
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Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy
In: Journal of the American Chemical Society 147 (2025), p. 32799-32808
ISSN: 0002-7863
DOI: 10.1021/jacs.5c08659 - , , , , :
Interferometric scattering microscopy
In: Nature Reviews Methods Primers 5 (2025), Article No.: 23
ISSN: 2662-8449
DOI: 10.1038/s43586-025-00391-1 - , , , , , , :
Highly Efficient Organic Single-Photon Source Operating at Cryogenic Temperatures
2025 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2025 (Munich, DEU, 23. June 2025 – 27. June 2025)
In: 2025 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2025 2025
DOI: 10.1109/CLEO/EUROPE-EQEC65582.2025.11109484 - , , , , :
Cryo–light microscopy with angstrom precision deciphers structural conformations of PIEZO1 in its native state
In: Science Advances 11 (2025), Article No.: eadw4402
ISSN: 2375-2548
DOI: 10.1126/sciadv.adw4402 - , , , , , :
On-Chip Stark Tuning of Molecular Resonances in Nanoprinted Crystals
2025 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2025 (Munich, DEU, 23. June 2025 – 27. June 2025)
In: 2025 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2025 2025
DOI: 10.1109/CLEO/EUROPE-EQEC65582.2025.11109106 - , , , , :
Hybridization of molecules via a common photonic mode
In: Proceedings of the National Academy of Sciences of the United States of America 122 (2025), Article No.: e2505161122
ISSN: 0027-8424
DOI: 10.1073/pnas.2505161122 - , , , , , , , , , , , , , :
Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome
In: Small (2025)
ISSN: 1613-6829
DOI: 10.1002/smll.202502551 - , , , , , , , , , , , , , , , :
Lipidic folding pathway of α-Synuclein via a toxic oligomer
In: Nature Communications 16 (2025), p. 760-
ISSN: 2041-1723
DOI: 10.1038/s41467-025-55849-3 - , , , , , :
Electrostatic All-Passive Force Clamping of Charged Nanoparticles
In: ACS nano (2025)
ISSN: 1936-0851
DOI: 10.1021/acsnano.4c17299 - , :
Supported Lipid Bilayers as Stochastic Conveyor Belt for Delivery to the Near Field of Nanoscopic Structures
In: Journal of Physical Chemistry C 129 (2025), p. 495-499
ISSN: 1932-7447
DOI: 10.1021/acs.jpcc.4c06908 - , , , , , , , , , , , , , :
Mechanism of sensor kinase CitA transmembrane signaling
In: Nature Communications 16 (2025), Article No.: 935
ISSN: 2041-1723
DOI: 10.1038/s41467-024-55671-3
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A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control
In: Nature methods (2024)
ISSN: 1548-7105
DOI: 10.1038/s41592-024-02177-x - , , :
Long-Range Three-Dimensional Tracking of Nanoparticles Using Interferometric Scattering Microscopy
In: ACS nano (2024)
ISSN: 1936-0851
DOI: 10.1021/acsnano.4c08435 - , , , , :
Measuring Concentration of Nanoparticles in Polydisperse Mixtures Using Interferometric Nanoparticle Tracking Analysis
In: ACS nano (2024)
ISSN: 1936-0851
DOI: 10.1021/acsnano.4c04396 - , , , , , , :
iSCAT microscopy and particle tracking with tailored spatial coherence
In: Optica 11 (2024), p. 1030-1038
ISSN: 2334-2536
DOI: 10.1364/OPTICA.523788 - , , , , , , , :
An optofluidic antenna for enhancing the sensitivity of single-emitter measurements
In: Nature Communications 15 (2024), Article No.: 2545
ISSN: 2041-1723
DOI: 10.1038/s41467-024-46730-w - , , , , , , , , :
High-Resolution Cryogenic Spectroscopy of Single Molecules in Nanoprinted Crystals
In: ACS nano (2024)
ISSN: 1936-0851
DOI: 10.1021/acsnano.4c02003 - :
Essay: Exploring the Physics of Basic Medical Research
In: Physical Review Letters 132 (2024), Article No.: 090001
ISSN: 0031-9007
DOI: 10.1103/PhysRevLett.132.090001
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Breaking new ground in protein detection: Self-supervised machine learning and iSCAT enable label-free detection of single proteins below 10 kDa
Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 – Part of Optica Biophotonics Congress: Optics in the Life Sciences (Vancouver, BC, CAN, 24. April 2023 – 27. April 2023)
In: Bio-Optics: Design and Application in Proceedings Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 2023
DOI: 10.1364/BODA.2023.JW2A.3 - , , , , :
Self-supervised machine learning pushes the sensitivity limit in label-free detection of single proteins below 10 kDa
In: Nature methods (2023)
ISSN: 1548-7105
DOI: 10.1038/s41592-023-01778-2 - , , , , , , :
Label-free discrimination of extracellular vesicles from large lipoproteins.
In: Journal of Extracellular Vesicles 12 (2023)
ISSN: 2001-3078
DOI: 10.1002/jev2.12348 - , , , , :
Confocal interferometric scattering microscopy reveals 3D nanoscopic structure and dynamics in live cells
In: Nature Communications 14 (2023), p. 1962-
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37497-7 - , , :
Insights into protein structure using cryogenic light microscopy
In: Biochemical Society Transactions 51 (2023), p. 2041-2059
ISSN: 0300-5127
DOI: 10.1042/BST20221246 - , , , , , , :
Quantum Efficiency of Single Dibenzoterrylene Molecules in p-Dichlorobenzene at Cryogenic Temperatures
In: Journal of Physical Chemistry B 127 (2023), p. 5353-5359
ISSN: 1520-6106
DOI: 10.1021/acs.jpcb.3c01755 - , , , , , :
On-chip interference of scattering from two individual molecules
In: Optica 10 (2023), p. 1595-1601
ISSN: 2334-2536
DOI: 10.1364/OPTICA.502221 - , , , , , , :
Spectral splitting of a stimulated Raman transition in a single molecule
In: Physical Review Research 5 (2023), Article No.: 043244
ISSN: 2643-1564
DOI: 10.1103/PhysRevResearch.5.043244
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Next-generation particle sizing: interferometric nanoparticle tracking analysis (iNTA)
Optical Sensors, Sensors 2022 (Vancouver, BC, CAN, 11. July 2022 – 15. July 2022)
In: Optics InfoBase Conference Papers 2022 - , , :
Engineering long-lived vibrational states for an organic molecule
12th International Conference on Metamaterials, Photonic Crystals and Plasmonics, META 2022 (Torremolinos, 19. July 2022 – 22. July 2022)
In: Said Zouhdi (ed.): International Conference on Metamaterials, Photonic Crystals and Plasmonics 2022 - , , , , :
Precision size and refractive index analysis of weakly scattering nanoparticles in polydispersions
In: Nature Methods (2022)
ISSN: 1548-7091
DOI: 10.1038/s41592-022-01460-z - , , , , :
Nanoscale Imaging of Live Cells with Confocal Interferometric Scattering Microscopy (iSCAT)
Microscopy Histopathology and Analytics, Microscopy 2022 (Fort Lauderdale, FL, USA, 24. April 2022 – 27. April 2022)
In: Optics InfoBase Conference Papers 2022 - , , , , , :
Robust Tipless Positioning Device for Near-Field Investigations: Press and Roll Scan (PROscan)
In: ACS nano (2022)
ISSN: 1936-0851
DOI: 10.1021/acsnano.2c05047 - , , :
Long-Range High-Speed 3D Tracking via Interferometric Scattering Microscopy
Clinical and Translational Biophotonics, Translational 2022 (Fort Lauderdale, FL, USA, 24. April 2022 – 27. April 2022)
In: Optics InfoBase Conference Papers 2022 - , , :
Deciphering a hexameric protein complex with Angstrom optical resolution
In: eLife 11 (2022)
ISSN: 2050-084X
DOI: 10.7554/eLife.76308 - , , , , , :
Optimized analysis for sensitive detection and analysis of single proteins via interferometric scattering microscopy
In: Journal of Physics D: Applied Physics 55 (2022)
ISSN: 0022-3727
DOI: 10.1088/1361-6463/ac2f68 - , , , , , , , , :
High-resolution vibronic spectroscopy of a single molecule embedded in a crystal
In: Journal of Chemical Physics 156 (2022), Article No.: 104301
ISSN: 0021-9606
DOI: 10.1063/5.0081297
